New Two Reagent HbA1c Kit
Diagnosis of HbA1c:
The determination of glucose shows only the actual blood glucose level, but the blood glucose level is dependent on nutrition and daily rhythms. For the clinical diagnosis of Glycemia over a longer period the glycated hemoglobines can be determined as long termed parameter. The higher the blood glucose level is the higher is the percentage of HbA1c.
Possible interference factors:
Too high values (exemplary)
- Medicaments (e.g. high doses of Acetylsalicylicacid)
- Organ transplantation
- Hb-pathia (HbF etc.)
- Kidney insufficiency
- Anemias
Too low values (exemplary) - Hb-pathia (HbS etc.)
- Loss of blood
- Chronically kidney insufficiency
- Medicaments (e.g. Erythropoetin)
- Livercirrhosis
- Folic acid deficiency
Significance of values:
Healthy adults: 4.5-6.0% (26-42 mmol/mol)
Values higher than 6% indicate, that the blood glucose level was increased for a longer time.
Principle:
The Centronic HbA1c test is based on the interaction of a latex bound mouse antihuman HbA1c monoclonal antibody with the HbA1c to build a complex. Finally an agglutination is formed by interaction of a goat antimouse IgG polyclonal antibody with the monoclonal antibody. The agglutination is measured photometrically.
The calibration is done with four available levels of the Centronic calibration set.
Advantages of the New Reagent:
- Stable two reagent system
- Many tests on the market work with 3 reagents: No premixing of reagent 2a and 2b more necessary
- Excellent correlation to HPLC (Tosoh)
- Very user friendly
- Analyser system pack available
- Many applications for analysers available
If you have questions, please contact our sales departement under sales@centronic-gmbh.com
